Share Email Print
cover

Proceedings Paper

Effect of injection technique on temporal parametric imaging derived from digital subtraction angiography in patient specific phantoms
Author(s): Ciprian N. Ionita; Victor L. Garcia; Daniel R. Bednarek; Kenneth V. Snyder; Adnan H. Siddiqui; Elad I. Levy; Stephen Rudin
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Parametric imaging maps (PIM’s) derived from digital subtraction angiography (DSA) for the cerebral arterial flow assessment in clinical settings have been proposed, but experiments have yet to determine the reliability of such studies. For this study, we have observed the effects of different injection techniques on PIM’s. A flow circuit set to physiologic conditions was created using an internal carotid artery phantom. PIM’s were derived for two catheter positions, two different contrast bolus injection volumes (5ml and 10 ml), and four injection rates (5, 10, 15 and 20 ml/s). Using a gamma variate fitting approach, we derived PIM’s for mean-transit-time (MTT), time-to-peak (TTP) and bolus-arrivaltime (BAT). For the same injection rates, a larger bolus resulted in an increased MTT and TTP, while a faster injection rate resulted in a shorter MTT, TTP, and BAT. In addition, the position of the catheter tip within the vasculature directly affected the PIM. The experiment showed that the PIM is strongly correlated with the injection conditions, and, therefore, they have to be interpreted with caution. PIM images must be taken from the same patient to be able to be meaningfully compared. These comparisons can include pre- and post-treatment images taken immediately before and after an interventional procedure or simultaneous arterial flow comparisons through the left and right cerebral hemispheres. Due to the strong correlation between PIM and injection conditions, this study indicates that this assessment method should be used only to compare flow changes before and after treatment within the same patient using the same injection conditions.

Paper Details

Date Published: 13 March 2014
PDF: 12 pages
Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90380L (13 March 2014); doi: 10.1117/12.2041347
Show Author Affiliations
Ciprian N. Ionita, Toshiba Stroke and Vascular Research Ctr., Univ. at Buffalo (United States)
Victor L. Garcia, Toshiba Stroke and Vascular Research Ctr., Univ. at Buffalo (United States)
Daniel R. Bednarek, Toshiba Stroke and Vascular Research Ctr., Univ. at Buffalo (United States)
Kenneth V. Snyder, Toshiba Stroke and Vascular Research Ctr., Univ. at Buffalo (United States)
Adnan H. Siddiqui, Toshiba Stroke and Vascular Research Ctr., Univ. at Buffalo (United States)
Elad I. Levy, Toshiba Stroke and Vascular Research Ctr., Univ. at Buffalo (United States)
Stephen Rudin, Toshiba Stroke and Vascular Research Ctr., Univ. at Buffalo (United States)


Published in SPIE Proceedings Vol. 9038:
Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
Robert C. Molthen; John B. Weaver, Editor(s)

© SPIE. Terms of Use
Back to Top