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Proceedings Paper

Mechanistic studies of systemic immune responses induced by laser-nanotechnology
Author(s): Wei R. Chen; Feifan Zhou; Brock Henderson; Bailey Vasquez; Hong Liu; Tomas Hode; Robert E. Nordquist
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Paper Abstract

With the help of the specific absorption spectrum of carbon nanotubes, we achieved selective photothermal tumor cell destruction, particularly using a near-infrared laser to reduce potential damage to untargeted tissues. Combined with immunological stimulation, using a novel adjuvant, we also observed the anti-tumor immune responses when treating animal tumors using the laser-nano treatment. In fact, the local application of laser-nano-immunotherapy appeared to result in a systemic curative effect. In our mechanistic study, we found that the laser-nano-immuno treatment can activate antigen-presenting cells, such as dendritic cells (DCs). More importantly, the uptake and presentation of antigens by these antigen presenting cells were significantly enhanced, as shown by the strong binding of tumor cells and DCs as well as the proliferation of T cells caused by the DCs after the DCs had been incubated with laser-nano-immuno treated tumors. These cellular observations provide evidence that a systemic anti-tumor immune response was induced by the combination of laser and nanotechnology.

Paper Details

Date Published: 27 February 2014
PDF: 6 pages
Proc. SPIE 8944, Biophotonics and Immune Responses IX, 89440U (27 February 2014); doi: 10.1117/12.2041265
Show Author Affiliations
Wei R. Chen, Univ. of Central Oklahoma (United States)
Feifan Zhou, South China Normal Univ. (China)
Brock Henderson, Univ. of Central Oklahoma (United States)
Bailey Vasquez, Univ. of Central Oklahoma (United States)
Hong Liu, The Univ. of Oklahoma (United States)
Tomas Hode, Immunophotonics, Inc. (United States)
Robert E. Nordquist, Immunophotonics, Inc. (United States)

Published in SPIE Proceedings Vol. 8944:
Biophotonics and Immune Responses IX
Wei R. Chen, Editor(s)

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