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Proceedings Paper

Microencapsulation of curcumin in PLGA microcapsules by coaxial flow focusing
Author(s): Fan Lei; Ting Si; Xisheng Luo; Ronald X. Xu
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Paper Abstract

Curcumin-loaded PLGA microcapsules are fabricated by a liquid-driving coaxial flow focusing device. In the process, a stable coaxial cone-jet configuration is formed under the action of a coflowing liquid stream and the coaxial liquid jet eventually breaks up into microcapsules because of flow instability. This process can be well controlled by adjusting the flow rates of three phases including the driving PVA water solution, the outer PLGA ethyl acetate solution and the inner curcumin propylene glycol solution. Confocal and SEM imaging methods clearly indicate the core-shell structure of the resultant microcapsules. The encapsulation rate of curcumin in PLGA is measured to be more than 70%, which is much higher than the tranditional methods such as emulsion. The size distribution of resultant microcapsules under different conditions is presented and compared. An in vitro release simulation platform is further developed to verify the feasibility and reliability of the method.

Paper Details

Date Published: 7 March 2014
PDF: 9 pages
Proc. SPIE 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI, 89560J (7 March 2014); doi: 10.1117/12.2041072
Show Author Affiliations
Fan Lei, Univ. of Science and Technology of China (China)
Ting Si, Univ. of Science and Technology of China (China)
Xisheng Luo, Univ. of Science and Technology of China (China)
Ronald X. Xu, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 8956:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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