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Proceedings Paper

Microencapsulation of multiple components by compound-fluidic electro-flow focusing
Author(s): Chuansheng Yin; Ting Si; Peng Gao; Fan Lei; Ronald X. Xu
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Paper Abstract

Microcapsules with multiple components inside a biodegradable shell are of great significance in various applications such as biomedicine, biochemistry, sustained drug delivery and image-guided therapy. Here we report a compoundfluidic electro-flow focusing (CFEFF) process that has the potential to one-step envelope multiple drugs and imaging agents separately into a single microcapsule. In this method, a compound needle is assembled by embedding two parallel thin inner needles into a relatively large outer needle. Two kinds of core fluids flow through the inner needles separately and the shell fluid flows through the outer needle. Under the action of aerodynamic and electric driving forces, stable cone-jet configurations can be obtained, resulting in multilayered microcapsules after the breakup of the compound liquid jet because of flow instability. The feasibility and effectiveness of using this CFEFF method to encapsulate multiple components into one shell is verified experimentally. The effects of various process parameters on the morphology and size of the microcapsules are further studied.

Paper Details

Date Published: 17 February 2014
PDF: 8 pages
Proc. SPIE 8937, Multimodal Biomedical Imaging IX, 89370M (17 February 2014); doi: 10.1117/12.2041068
Show Author Affiliations
Chuansheng Yin, Univ. of Science and Technology of China (China)
Ting Si, Univ. of Science and Technology of China (China)
Peng Gao, Univ. of Science and Technology of China (China)
Fan Lei, Univ. of Science and Technology of China (China)
Ronald X. Xu, Univ. of Science and Technology of China (China)
The Ohio State Univ. (United States)

Published in SPIE Proceedings Vol. 8937:
Multimodal Biomedical Imaging IX
Fred S. Azar; Xavier Intes, Editor(s)

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