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Proceedings Paper

Photoacoustic imaging of prostate brachytherapy seeds with transurethral light delivery
Author(s): Muyinatu A. Lediju Bell; Xiaoyu Guo; Danny Y. Song; Emad M. Boctor
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Paper Abstract

We present a novel approach to photoacoustic imaging of prostate brachytherapy seeds utilizing an existing urinary catheter for transurethral light delivery. Two canine prostates were surgically implanted with brachyther- apy seeds under transrectal ultrasound guidance. One prostate was excised shortly after euthanasia and fixed in gelatin. The second prostate was imaged in the native tissue environment shortly after euthanasia. A urinary catheter was inserted in the urethra of each prostate. A 1-mm core diameter optical fiber coupled to a 1064 nm Nd:YAG laser was inserted into the urinary catheter. Light from the fiber was either directed mostly parallel to the fiber axis (i.e. end-fire fire) or mostly 90° to the fiber axis (i.e. side-fire fiber). An Ultrasonix SonixTouch scanner, transrectal ultrasound probe with curvilinear (BPC8-4) and linear (BPL9-5) arrays, and DAQ unit were utilized for synchronized laser light emission and photoacoustic signal acquisition. The implanted brachytherapy seeds were visualized at radial distances of 6-16 mm from the catheter. Multiple brachytherapy seeds were si- multaneously visualized with each array of the transrectal probe using both delay-and-sum (DAS) and short-lag spatial coherence (SLSC) beamforming. This work is the first to demonstrate the feasibility of photoacoustic imaging of prostate brachytherapy seeds using a transurethral light delivery method.

Paper Details

Date Published: 3 March 2014
PDF: 6 pages
Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 89430N (3 March 2014); doi: 10.1117/12.2040751
Show Author Affiliations
Muyinatu A. Lediju Bell, Johns Hopkins Univ. (United States)
Xiaoyu Guo, Johns Hopkins Univ. (United States)
Danny Y. Song, Johns Hopkins Univ. School of Medicine (United States)
Emad M. Boctor, Johns Hopkins Univ. (United States)
Johns Hopkins Univ. School of Medicine (United States)

Published in SPIE Proceedings Vol. 8943:
Photons Plus Ultrasound: Imaging and Sensing 2014
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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