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Proceedings Paper

A dual-modality photoacoustic and ultrasound imaging system for noninvasive sentinel lymph node detection: preliminary clinical results
Author(s): Todd N. Erpelding; Alejandro Garcia-Uribe; Arie Krumholz; Haixin Ke; Konstantin Maslov; Catherine Appleton; Julie Margenthaler; Lihong V. Wang
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Paper Abstract

Sentinel lymph node biopsy (SLNB) has emerged as an accurate, less invasive alternative to axillary lymph node dissection, and it has rapidly become the standard of care for patients with clinically node-negative breast cancer. The sentinel lymph node (SLN) hypothesis states that the pathological status of the axilla can be accurately predicted by determining the status of the first (i.e., sentinel) lymph nodes that drain from the primary tumor. Physicians use radio-labeled sulfur colloid and/or methylene blue dye to identify the SLN, which is most likely to contain metastatic cancer cells. However, the surgical procedure causes morbidity and associated expenses. To overcome these limitations, we developed a dual-modality photoacoustic and ultrasound imaging system to noninvasively detect SLNs based on the accumulation of methylene blue dye. Ultimately, we aim to guide percutaneous needle biopsies and provide a minimally invasive method for axillary staging of breast cancer. The system consists of a tunable dye laser pumped by a Nd:YAG laser, a commercial ultrasound imaging system (Philips iU22), and a multichannel data acquisition system which displays co-registered photoacoustic and ultrasound images in real-time. Our clinical results demonstrate that real-time photoacoustic imaging can provide sensitive and specific detection of methylene blue dye in vivo. While preliminary studies have shown that in vivo detection of SLNs by using co-registered photoacoustic and ultrasound imaging is feasible, further investigation is needed to demonstrate robust SLN detection.

Paper Details

Date Published: 3 March 2014
PDF: 6 pages
Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894359 (3 March 2014); doi: 10.1117/12.2040475
Show Author Affiliations
Todd N. Erpelding, Philips Research North America (United States)
Alejandro Garcia-Uribe, Washington Univ. in St. Louis (United States)
Arie Krumholz, Washington Univ. in St. Louis (United States)
Haixin Ke, Washington Univ. in St. Louis (United States)
Konstantin Maslov, Washington Univ. in St. Louis (United States)
Catherine Appleton, Washington Univ. School of Medicine (United States)
Julie Margenthaler, Washington Univ. School of Medicine (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


Published in SPIE Proceedings Vol. 8943:
Photons Plus Ultrasound: Imaging and Sensing 2014
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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