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Proceedings Paper

Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter
Author(s): Tsung-Han Tsai; Osman O. Ahsen; Hsiang-Chieh Lee; Kaicheng Liang; Michael G. Giacomelli; Benjamin M. Potsaid; Yuankai K. Tao; Vijaysekhar Jayaraman; Martin F. Kraus; Joachim Hornegger; Marisa Figueiredo; Qin Huang; Hiroshi Mashimo; Alex E. Cable; James G. Fujimoto
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Paper Abstract

We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was 3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm with a pixel spacing of 5 μm in the longitudinal direction. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing standard upper and lower endoscopy at the Veterans Affairs Boston Healthcare System (VABHS). Patients with Barrett’s esophagus, dysplasia, and inflammatory bowel disease were imaged. The use of distally actuated imaging catheters allowed OCT imaging with more flexibility such as volumetric imaging in the terminal ileum and the assessment of the hiatal hernia using retroflex imaging. The high rotational stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face and cross-sectional imaging. The ability to perform 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies to investigate the ability of OCT to detect pathology as well as assess treatment response.

Paper Details

Date Published: 4 March 2014
PDF: 6 pages
Proc. SPIE 8927, Endoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine, 89270T (4 March 2014); doi: 10.1117/12.2040417
Show Author Affiliations
Tsung-Han Tsai, Massachusetts Institute of Technology (United States)
Osman O. Ahsen, Massachusetts Institute of Technology (United States)
Hsiang-Chieh Lee, Massachusetts Institute of Technology (United States)
Kaicheng Liang, Massachusetts Institute of Technology (United States)
Michael G. Giacomelli, Massachusetts Institute of Technology (United States)
Benjamin M. Potsaid, Massachusetts Institute of Technology (United States)
Thorlabs, Inc. (United States)
Yuankai K. Tao, Massachusetts Institute of Technology (United States)
Vijaysekhar Jayaraman, Praevium Research, Inc. (United States)
Martin F. Kraus, Massachusetts Institute of Technology (United States)
Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany)
Joachim Hornegger, Friedrich-Alexander-Univ. Erlangen-Nürnberg (Germany)
Marisa Figueiredo, VA Boston Healthcare System (United States)
Harvard Medical School (United States)
Qin Huang, VA Boston Healthcare System (United States)
Harvard Medical School (United States)
Hiroshi Mashimo, VA Boston Healthcare System (United States)
Harvard Medical School (United States)
Alex E. Cable, Thorlabs Inc. (United States)
James G. Fujimoto, Massachusetts Institute of Technology (United States)


Published in SPIE Proceedings Vol. 8927:
Endoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine
Melissa J. Suter; Guillermo J. Tearney; Thomas D. Wang; Stephen Lam; Matthew Brenner, Editor(s)

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