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Proceedings Paper

Point-of-care optical tool to detect early stage of hemorrhage and shock
Author(s): Rajan S. Gurjar; Suzannah L. Riccardi; Blair D. Johnson; Christopher P. Johnson; Norman A. Paradis; Michael J. Joyner; David E. Wolf
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Paper Abstract

There is a critical unmet clinical need for a device that can monitor and predict the onset of shock: hemorrhagic shock or bleeding to death, septic shock or systemic infection, and cardiogenic shock or blood flow and tissue oxygenation impairment due to heart attack. Together these represent 141 M patients per year. We have developed a monitor for shock based on measuring blood flow in peripheral (skin) capillary beds using diffuse correlation spectroscopy, a form of dynamic light scattering, and have demonstrated proof-of-principle both in pigs and humans. Our results show that skin blood flow measurement, either alone or in conjunction with other hemodynamic properties such as heart rate variability, pulse pressure variability, and tissue oxygenation, can meet this unmet need in a small self-contained patch-like device in conjunction with a hand-held processing unit. In this paper we describe and discuss the experimental work and the multivariate statistical analysis performed to demonstrate proof-of-principle of the concept.

Paper Details

Date Published: 28 February 2014
PDF: 11 pages
Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 89510K (28 February 2014); doi: 10.1117/12.2040267
Show Author Affiliations
Rajan S. Gurjar, Radiation Monitoring Devices, Inc. (United States)
Suzannah L. Riccardi, Radiation Monitoring Devices, Inc. (United States)
Blair D. Johnson, Mayo Clinic (United States)
Christopher P. Johnson, Mayo Clinic (United States)
Norman A. Paradis, Dartmouth-Hitchcock Medical Ctr. (United States)
Michael J. Joyner, Mayo Clinic (United States)
David E. Wolf, Radiation Monitoring Devices, Inc. (United States)

Published in SPIE Proceedings Vol. 8951:
Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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