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Proceedings Paper

A surgical navigation system for non-contact diffuse optical tomography and intraoperative cone-beam CT
Author(s): Michael J. Daly; Nidal Muhanna; Harley Chan; Brian C. Wilson; Jonathan C. Irish; David A. Jaffray
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Paper Abstract

A freehand, non-contact diffuse optical tomography (DOT) system has been developed for multimodal imaging with intraoperative cone-beam CT (CBCT) during minimally-invasive cancer surgery. The DOT system is configured for near-infrared fluorescence imaging with indocyanine green (ICG) using a collimated 780 nm laser diode and a nearinfrared CCD camera (PCO Pixelfly USB). Depending on the intended surgical application, the camera is coupled to either a rigid 10 mm diameter endoscope (Karl Storz) or a 25 mm focal length lens (Edmund Optics). A prototype flatpanel CBCT C-Arm (Siemens Healthcare) acquires low-dose 3D images with sub-mm spatial resolution. A 3D mesh is extracted from CBCT for finite-element DOT implementation in NIRFAST (Dartmouth College), with the capability for soft/hard imaging priors (e.g., segmented lymph nodes). A stereoscopic optical camera (NDI Polaris) provides real-time 6D localization of reflective spheres mounted to the laser and camera. Camera calibration combined with tracking data is used to estimate intrinsic (focal length, principal point, non-linear distortion) and extrinsic (translation, rotation) lens parameters. Source/detector boundary data is computed from the tracked laser/camera positions using radiometry models. Target registration errors (TRE) between real and projected boundary points are ~1-2 mm for typical acquisition geometries. Pre-clinical studies using tissue phantoms are presented to characterize 3D imaging performance. This translational research system is under investigation for clinical applications in head-and-neck surgery including oral cavity tumour resection, lymph node mapping, and free-flap perforator assessment.

Paper Details

Date Published: 19 February 2014
PDF: 7 pages
Proc. SPIE 8937, Multimodal Biomedical Imaging IX, 893703 (19 February 2014); doi: 10.1117/12.2040176
Show Author Affiliations
Michael J. Daly, Univ. of Toronto (Canada)
Univ. Health Network (Canada)
Nidal Muhanna, Univ. Health Network (Canada)
Harley Chan, Univ. Health Network (Canada)
Brian C. Wilson, Univ. Health Network (Canada)
Princess Margaret Cancer Ctr. (Canada)
Jonathan C. Irish, Univ. Health Network (Canada)
Princess Margaret Cancer Ctr. (Canada)
David A. Jaffray, Univ. of Toronto (Canada)
Univ. Health Network (Canada)
Princess Margaret Cancer Ctr. (Canada)

Published in SPIE Proceedings Vol. 8937:
Multimodal Biomedical Imaging IX
Fred S. Azar; Xavier Intes, Editor(s)

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