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Proceedings Paper

The development of a simplified epithelial tissue phantom for the evaluation of an autofluorescence mitigation algorithm
Author(s): Vivian W. Hou; Chenying Yang; Leonard Y. Nelson; Eric J. Seibel
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Paper Abstract

Previously we developed an ultrathin, flexible, multimodal scanning fiber endoscope (SFE) for concurrent white light and fluorescence imaging. Autofluorescence (AF) arising from endogenous fluorophores (primarily collagen in the esophagus) act as major confounders in fluorescence-aided detection. To address the issue of AF, a real-time mitigation algorithm was developed and has been show to successfully remove AF during SFE imaging. To test our algorithm, we previously developed flexible, color-matched, synthetic phantoms featuring a homogenous distribution of collagen. In order to more rigorously test the AF mitigation algorithm, a phantom that better mimicked the in-vivo distribution of collagen in tissue was developed.

Paper Details

Date Published: 3 March 2014
PDF: 8 pages
Proc. SPIE 8945, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI, 894506 (3 March 2014); doi: 10.1117/12.2040167
Show Author Affiliations
Vivian W. Hou, Univ. of Washington (United States)
Chenying Yang, Univ. of Washington (United States)
Leonard Y. Nelson, Univ. of Washington (United States)
Eric J. Seibel, Univ. of Washington (United States)


Published in SPIE Proceedings Vol. 8945:
Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI
Robert J. Nordstrom; Jean-Pierre Bouchard; David W. Allen, Editor(s)

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