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Proceedings Paper

Detecting apoptosis in vivo and ex vivo using spectroscopic OCT and dynamic light scattering
Author(s): Golnaz Farhat; Anoja Giles; Adrian Mariampillai; Victor X. D. Yang; Gregory J. Czarnota; Michael C. Kolios
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Paper Abstract

We present an in vivo implementation of a multi-parametric technique for detecting apoptosis using optical coherence tomography in a mouse tumor model. Solid tumors were grown from acute myeloid leukemia cells in the hind leg of SCID mice and treated with a single dose of cisplatin and dexamethasone to induce apoptosis. Both spectral features and speckle decorrelation times indicated good consistency between control mice and reasonable agreement with in vitro measurements. The integrated backscatter increased significantly in tumors responding to treatment while the spectral slope and decorrelation time did not show significant changes. This study demonstrates the feasibility of using spectroscopic OCT and dynamic light scattering for treatment monitoring in vivo.

Paper Details

Date Published: 11 March 2014
PDF: 6 pages
Proc. SPIE 8952, Biomedical Applications of Light Scattering VIII, 89520K (11 March 2014); doi: 10.1117/12.2040075
Show Author Affiliations
Golnaz Farhat, Univ. of Toronto (Canada)
Sunnybrook Health Sciences Ctr. (Canada)
Anoja Giles, Sunnybrook Health Sciences Ctr. (Canada)
Adrian Mariampillai, Ryerson Univ. (Canada)
Victor X. D. Yang, Sunnybrook Health Sciences Ctr. (Canada)
Ryerson Univ. (Canada)
Gregory J. Czarnota, Univ. of Toronto (Canada)
Sunnybrook Health Sciences Ctr. (Canada)
Michael C. Kolios, Ryerson Univ. (Canada)


Published in SPIE Proceedings Vol. 8952:
Biomedical Applications of Light Scattering VIII
Adam Wax; Vadim Backman, Editor(s)

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