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Proceedings Paper

BODIPY derivatives as molecular photoacoustic contrast agents
Author(s): Samir Laoui; Seema Bag; Olivier Dantiste; Mathieu Frenette; Maryam Hatamimoslehabadi; Stephanie Bellinger-Buckley; Jen-Chieh Tseng; Jonathan Rochford; Chandra Yelleswarapu
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Paper Abstract

Photoacoustic imaging (PAI) is emerging as a key in vivo imaging technique. Endogenous contrast agents alone are insufficient to obtain high contrast images necessitating a need for synthetic exogenous contrast agents. In recent years a great deal of research has been devoted to the development of nanoparticle based contrast agents with little effort on molecular systems. Here we report on the design and evaluation of BODIPY inspired molecular photoacoustic contrast agents (MPACs). Through chemical modification of the established BODIPY fluorophore, increasing its vibrational freedom and appending with non-emissive functionalities, it is demonstrated that the S0-S1 absorbed excitation energy is redirected towards a nonradiative excited-state decay pathway. Optical and photoacoustic characterization of the modified BODIPY MPACs demonstrates a stronger photoacoustic signal compared to the corresponding fluorescent BODIPY probes.

Paper Details

Date Published: 5 March 2014
PDF: 9 pages
Proc. SPIE 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI, 895609 (5 March 2014); doi: 10.1117/12.2040057
Show Author Affiliations
Samir Laoui, Univ. of Massachusetts Boston (United States)
Seema Bag, Univ. of Massachusetts Boston (United States)
Olivier Dantiste, Univ. of Massachusetts Boston (United States)
Mathieu Frenette, Univ. of Massachusetts Boston (United States)
Maryam Hatamimoslehabadi, Univ. of Massachusetts Boston (United States)
Stephanie Bellinger-Buckley, Univ. of Massachusetts Boston (United States)
Jen-Chieh Tseng, Lurie Family Imaging Ctr. (United States)
Jonathan Rochford, Univ. of Massachusetts Boston (United States)
Chandra Yelleswarapu, Univ. of Massachusetts Boston (United States)


Published in SPIE Proceedings Vol. 8956:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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