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Proceedings Paper

Development of a fiber based Raman probe compatible with interventional magnetic resonance imaging
Author(s): Praveen C. Ashok; Bavishna B. Praveen; Martin Rube; Benjamin Cox; Andreas Melzer; Kishan Dholakia
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Paper Abstract

Raman spectroscopy has proven to be a powerful tool for discriminating between normal and abnormal tissue types. Fiber based Raman probes have demonstrated its potential for in vivo disease diagnostics. Combining Raman spectroscopy with Magnetic Resonance Imaging (MRI) opens up new avenues for MR guided minimally invasive optical biopsy. Although Raman probes are commercially available, they are not compatible with a MRI environment due to the metallic components which are used to align the micro-optic components such as filters and lenses at the probe head. Additionally they are not mechanically compatible with a typical surgical environment as factors such as sterility and length of the probe are not addressed in those designs. We have developed an MRI compatible fiber Raman probe with a disposable probe head hence maintaining sterility. The probe head was specially designed to avoid any material that would cause MR imaging artefacts. The probe head that goes into patient’s body had a diameter <1.5 mm so that it is compatible with biopsy needles and catheters. The probe has been tested in MR environment and has been proven to be capable of obtaining Raman signal while the probe is under real-time MR guidance.

Paper Details

Date Published: 27 February 2014
PDF: 6 pages
Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89351J (27 February 2014); doi: 10.1117/12.2039805
Show Author Affiliations
Praveen C. Ashok, Univ. of St. Andrews (United Kingdom)
Bavishna B. Praveen, Univ. of St. Andrews (United Kingdom)
Martin Rube, Univ. of Dundee (United Kingdom)
Benjamin Cox, Univ. of Dundee (United Kingdom)
Andreas Melzer, Univ. of Dundee (United Kingdom)
Kishan Dholakia, Univ. of St. Andrews (United Kingdom)


Published in SPIE Proceedings Vol. 8935:
Advanced Biomedical and Clinical Diagnostic Systems XII
Tuan Vo-Dinh; Anita Mahadevan-Jansen; Warren S. Grundfest, Editor(s)

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