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Proceedings Paper

Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates
Author(s): Anna Chiara De Luca; Peter Reader-Harris; Michael Mazilu; Stefano Managò; Stefania Mariggiò; Daniela Corda; Andrea Di Falco
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Paper Abstract

We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.

Paper Details

Date Published: 3 March 2014
PDF: 7 pages
Proc. SPIE 8957, Plasmonics in Biology and Medicine XI, 895709 (3 March 2014); doi: 10.1117/12.2039697
Show Author Affiliations
Anna Chiara De Luca, Institute of Protein Biochemsitry, CNR (Italy)
Peter Reader-Harris, Univ. of St. Andrews (United Kingdom)
Michael Mazilu, Univ. of St. Andrews (United Kingdom)
Stefano Managò, Institute of Protein Biochemsitry, CNR (Italy)
Stefania Mariggiò, Institute of Protein Biochemsitry, CNR (Italy)
Daniela Corda, Institute of Protein Biochemsitry, CNR (Italy)
Andrea Di Falco, Univ. of St. Andrews (United Kingdom)


Published in SPIE Proceedings Vol. 8957:
Plasmonics in Biology and Medicine XI
Tuan Vo-Dinh; Joseph R. Lakowicz, Editor(s)

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