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Proceedings Paper

Ultrabright and bleaching-resistant hybrid gold nanoparticles for confocal and two-photon fluorecence imaging
Author(s): P. L. Baldeck; J. Navarro; G. Micouin; A.-M. Gabudean; F. Lerouge; C. Monnerau; F. Chaput; C. Andraud; S. Parola
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Paper Abstract

We review our work on hybrid gold nanoparticles that are optimized for their bright fluorescence and photobleaching resistance. Our first goal in using gold nanoparticles is to load a large density of photoactive molecules onto a biocompatible nanoplatform. Our second goal is to optimize the molecule-gold nanoparticle interaction to improve the photoactive properties, in particular their photobleaching resistance. In this project gold nanoparticles have typical dimensions in the 50-100 nm that are suitable for in vivo imaging and photodynamic therapy. Their geometrical shapes include nanoshell, spheres, rods, bipyramids and stars.

Paper Details

Date Published: 7 March 2014
PDF: 4 pages
Proc. SPIE 8956, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI, 89560T (7 March 2014); doi: 10.1117/12.2039479
Show Author Affiliations
P. L. Baldeck, Lab. Interdisciplinaire de Physique, CNRS, Univ. Grenoble 1 (France)
Lab. de Chimie, CNRS, Univ. Lyon 1 (France)
J. Navarro, Lab. de Chimie, CNRS, Univ. Lyon 1 (France)
G. Micouin, Lab. de Chimie, CNRS, Univ. Lyon 1 (France)
A.-M. Gabudean, Lab. de Chimie, CNRS, Univ. Lyon 1 (France)
F. Lerouge, Lab. de Chimie, CNRS, Univ. Lyon 1 (France)
C. Monnerau, Lab. de Chimie, CNRS, Univ. Lyon 1 (France)
F. Chaput, Lab. de Chimie, CNRS, Univ. Lyon 1 (France)
C. Andraud, Lab. de Chimie, CNRS, Univ. Lyon 1 (France)
S. Parola, Lab. de Chimie, CNRS, Univ. Lyon 1 (France)


Published in SPIE Proceedings Vol. 8956:
Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications VI
Samuel Achilefu; Ramesh Raghavachari, Editor(s)

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