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Proceedings Paper

Iron-oxide colloidal nanoclusters: from fundamental physical properties to diagnosis and therapy
Author(s): Athanasia Kostopoulou; Konstantinos Brintakis; Alessandro Lascialfari; Mavroeidis Angelakeris; Marianna Vasilakaki; Kalliopi Trohidou; Alexios P. Douvalis; Stylianos Psycharakis; Anthi Ranella; Liberato Manna; Alexandros Lappas
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Paper Abstract

Research on magnetic nanocrystals attracts wide-spread interest because of their challenging fundamental properties, but it is also driven by problems of practical importance to the society, ranging from electronics (e.g. magnetic recording) to biomedicine. In that respect, iron oxides are model functional materials as they adopt a variety of oxidation states and coordinations that facilitate their use. We show that a promising way to engineer further their technological potential in diagnosis and therapy is the assembly of primary nanocrystals into larger colloidal entities, possibly with increased structural complexity. In this context, elevated-temperature nanochemistry (c.f. based on a polyol approach) permitted us to develop size-tunable, low-cytotoxicity iron-oxide nanoclusters, entailing iso-oriented nanocrystals, with enhanced magnetization. Experimental (magnetometry, electron microscopy, Mössbauer and NMR spectroscopies) results supported by Monte Carlo simulations are reviewed to show that such assemblies of surface-functionalized iron oxide nanocrystals have a strong potential for innovation. The clusters’ optimized magnetic anisotropy (including microscopic surface spin disorder) and weak ferrimagnetism at room temperature, while they do not undermine colloidal stability, endow them a profound advantage as efficient MRI contrast agents and hyperthermic mediators with important biomedical potential.

Paper Details

Date Published: 24 March 2014
PDF: 10 pages
Proc. SPIE 8955, Colloidal Nanoparticles for Biomedical Applications IX, 895517 (24 March 2014); doi: 10.1117/12.2039264
Show Author Affiliations
Athanasia Kostopoulou, Foundation for Research and Technology-Hellas (Greece)
Konstantinos Brintakis, Foundation for Research and Technology-Hellas (Greece)
Aristotle Univ. of Thessaloniki (Greece)
Alessandro Lascialfari, Univ. degli studi di Milano (Italy)
Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (Italy)
Mavroeidis Angelakeris, Aristotle Univ. of Thessaloniki (Greece)
Marianna Vasilakaki, National Ctr. for Scientific Research Demokritos (Greece)
Kalliopi Trohidou, National Ctr. for Scientific Research Demokritos (Greece)
Alexios P. Douvalis, Univ. of Ioannina (Greece)
Stylianos Psycharakis, Foundation for Research and Technology-Hellas (Greece)
Anthi Ranella, Foundation for Research and Technology-Hellas (Greece)
Liberato Manna, Istituto Italiano di Tecnologia (Italy)
Alexandros Lappas, Foundation for Research and Technology-Hellas (Greece)

Published in SPIE Proceedings Vol. 8955:
Colloidal Nanoparticles for Biomedical Applications IX
Wolfgang J. Parak; Marek Osinski; Kenji I. Yamamoto, Editor(s)

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