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Proceedings Paper

Quantitative spectrally resolved intraoperative fluorescence imaging for neurosurgical guidance in brain tumor surgery: pre-clinical and clinical results
Author(s): Pablo A. Valdés; Valerie L. Jacobs; Frederic Leblond; Brian C. Wilson; Keith D. Paulsen; David W. Roberts
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Paper Abstract

Fluorescence-guidance is a useful adjunct to maximize brain tumor resection but current commercial systems are limited by subjective assessment of fluorescence, low sensitivity and non-spectrally-resolved detection. We present a quantitative, spectrally-resolved system integrated onto a commercial neurosurgical microscope that performs spectrallyresolved detection and corrects for effects of tissue optical absorption and scattering on the detected fluorescence signal to image the true fluorophore concentration. Pre-clinical studies in rodent glioma models using multiple fluorophores (PpIX, fluorescein) and clinical studies demonstrate improved residual tumor tissue detection. This quantitative, spectrally-resolved technique opens the door to simultaneous image-guided surgery of multiple fluorophores in the visible and near infrared.

Paper Details

Date Published: 20 March 2014
PDF: 9 pages
Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 892809 (20 March 2014); doi: 10.1117/12.2039090
Show Author Affiliations
Pablo A. Valdés, Dartmouth College (United States)
Dartmouth Hitchcock Medical Ctr. (United States)
Valerie L. Jacobs, Dartmouth College (United States)
Frederic Leblond, Dartmouth College (United States)
Brian C. Wilson, Univ. of Toronto (Canada)
Keith D. Paulsen, Dartmouth College (United States)
Dartmouth Hitchcock Medical Ctr. (United States)
David W. Roberts, Dartmouth College (United States)
Dartmouth Hitchcock Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 8928:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
Henry Hirschberg; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Steen J. Madsen, Editor(s)

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