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Proceedings Paper

Measurement of the human esophageal cancer in an early stage with Raman spectroscopy
Author(s): Yasuhiro Maeda; Mika Ishigaki; Akinori Taketani; Bibin B. Andriana; Ryu Ishihara; Hidetoshi Sato
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Paper Abstract

The esophageal cancer has a tendency to transfer to another part of the body and the surgical operation itself sometimes gives high risk in vital function because many delicate organs exist near the esophagus. So the esophageal cancer is a disease with a high mortality. So, in order to lead a higher survival rate five years after the cancer’s treatment, the investigation of the diagnosis methods or techniques of the cancer in an early stage and support the therapy are required. In this study, we performed the ex vivo experiments to obtain the Raman spectra from normal and early-stage tumor (stage-0) human esophageal sample by using Raman spectroscopy. The Raman spectra are collected by the homemade Raman spectrometer with the wavelength of 785 nm and Raman probe with 600-um-diameter. The principal component analysis (PCA) is performed after collection of spectra to recognize which materials changed in normal part and cancerous pert. After that, the linear discriminant analysis (LDA) is performed to predict the tissue type. The result of PCA indicates that the tumor tissue is associated with a decrease in tryptophan concentration. Furthermore, we can predict the tissue type with 80% accuracy by LDA which model is made by tryptophan bands.

Paper Details

Date Published: 28 February 2014
PDF: 7 pages
Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 89510N (28 February 2014); doi: 10.1117/12.2038975
Show Author Affiliations
Yasuhiro Maeda, Kwansei Gakuin Univ. (Japan)
Mika Ishigaki, Kwansei Gakuin Univ. (Japan)
Akinori Taketani, Kwansei Gakuin Univ. (Japan)
Bibin B. Andriana, Kwansei Gakuin Univ. (Japan)
Ryu Ishihara, Osaka Medical Ctr. for Cancer and Cardiovascular Diseases (Japan)
Hidetoshi Sato, Kwansei Gakuin Univ. (Japan)

Published in SPIE Proceedings Vol. 8951:
Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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