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Proceedings Paper

Raman endoscopy for real time monitoring of anticancer drug treatment in colorectal tumors of live model mice
Author(s): Akinori Taketani; Mika Ishigaki; Bibin Bintan Andriana; Hidetoshi Sato
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Paper Abstract

The aim of the present study is to evaluate the capability of a miniaturized Raman endoscope (mRE) system to monitor the advancement of colorectal tumors in live model mice. The endoscope is narrow enough to observe the inside of the mouse colon under anesthesia. The mRE system allows to observe the tissues and to apply a miniaturized Raman probe for the measurement at any targeted point within the colon. Raman spectroscopy allows obtaining information about molecular composition without damaging the tissue (i.e., noninvasively). Continuous monitoring of the same tumor is carried out to study molecular alterations along with its advancement. The Raman spectra measured before and after the anticancer drug (5-FU) treatment indicated spectral changes in the tumor tissue. It suggests that the tumor is not cured but supposedly transformed to another tumor type after the treatment.

Paper Details

Date Published: 28 February 2014
PDF: 8 pages
Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 89510O (28 February 2014); doi: 10.1117/12.2038939
Show Author Affiliations
Akinori Taketani, Kwansei Gakuin Univ. (Japan)
Mika Ishigaki, Kwansei Gakuin Univ. (Japan)
Bibin Bintan Andriana, Kwansei Gakuin Univ. (Japan)
Hidetoshi Sato, Kwansei Gakuin Univ. (Japan)

Published in SPIE Proceedings Vol. 8951:
Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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