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Proceedings Paper

Live cell imaging based on surface plasmon-enhanced fluorescence microscopy using random nanostructures
Author(s): Youngjin Oh; Wonju Lee; Taehwang Son; Sook Young Kim; Jeon-Soo Shin; Donghyun Kim
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Paper Abstract

Localized surface plasmon enhanced microscopy based on nanoislands of random spatial distribution was demonstrated for imaging live cells and molecular interactions. Nanoislands were produced without lithography by high temperature annealing under various processing conditions. The localization of near-field distribution that is associated with localized surface plasmon on metallic random nanoislands was analyzed theoretically and experimentally in comparison with periodic nanostructures. For experimental validation in live cell imaging, mouse macrophage-like cell line stained with Alexa Fluor 488 was prepared on nanoislands. The results suggest the possibility of attaining the imaging resolution on the order of 80 nm.

Paper Details

Date Published: 20 February 2014
PDF: 7 pages
Proc. SPIE 8954, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI, 89540E (20 February 2014); doi: 10.1117/12.2038868
Show Author Affiliations
Youngjin Oh, Yonsei Univ. (Korea, Republic of)
Wonju Lee, Yonsei Univ. (Korea, Republic of)
Taehwang Son, Yonsei Univ. (Korea, Republic of)
Sook Young Kim, Yonsei Univ. (Korea, Republic of)
Jeon-Soo Shin, Yonsei Univ. (Korea, Republic of)
Donghyun Kim, Yonsei Univ. (Korea, Republic of)


Published in SPIE Proceedings Vol. 8954:
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XI
Alexander N. Cartwright; Dan V. Nicolau, Editor(s)

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