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Proceedings Paper

Quantitative measurement of biological substances in daily-life environment with the little-finger-size one-shot spectroscopic tomography
Author(s): Akane Ishida; Shun Sato; Sho Nakada; Satoru Suzuki; P. K. W. Abeygunawardhana; Kenji Wada; Akira Nishiyama; Ichiro Ishimaru
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Paper Abstract

In daily-life environment, the quantitative measurement of biological substances, such as the blood glucose level in the human skin, is strongly required to realize the non-invasive healthcare apparatus. Fourier-spectroscopic-tomography of the little-finger-size with high time-resolution and with the strong robustness for mechanical vibrations is proposed. The proposed method is a kind of near-common-path interferometer with spatial phase-shift method. We install the transmission-type relative-inclined phase-shifter on the optical Fourier transform plane of the infinity corrected optical system. The phase shifter is constructed with the cuboid and wedge prisms to give the relative phase-shift spatially between each half-flux of the objective beams. The interferograms from each single-bright-point on an objective surface in a line are formed as fringe patterns on 2-dimensional imaging array devices. And because the proposed method is based on the imaging optics, only emitted rays from a focal plane can contribute forming of interferograms. Thus, the measurement plane can be limited onto the focal plane only. From the spectroscopic tomography, only at a localized vessel area in human skins, we can get the pinpointed near-infrared spectroscopic data. And we can expect the improvement of the determination precision, because a Fourier spectroscopic-character is acquired from multiple intensity data in accordance with amount of phase-shift. From the statistical point of view, the gradation of detector is improved with the square root of sample number, based on t-distribution. We constructed the statistical model to assure the determination accuracy, and demonstrated the feasibility of the glucose sensor using liquid cells.

Paper Details

Date Published: 28 February 2014
PDF: 9 pages
Proc. SPIE 8951, Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics, 89510Y (28 February 2014); doi: 10.1117/12.2038836
Show Author Affiliations
Akane Ishida, Kagawa Univ. (Japan)
Shun Sato, Kagawa Univ. (Japan)
Sho Nakada, Kagawa Univ. (Japan)
Satoru Suzuki, Kagawa Univ. (Japan)
P. K. W. Abeygunawardhana, Kagawa Univ. (Japan)
Kenji Wada, Kagawa Univ. (Japan)
Akira Nishiyama, Kagawa Univ. (Japan)
Ichiro Ishimaru, Kagawa Univ. (Japan)

Published in SPIE Proceedings Vol. 8951:
Optical Diagnostics and Sensing XIV: Toward Point-of-Care Diagnostics
Gerard L. Coté, Editor(s)

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