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Proceedings Paper

Comparison of cone and cone shell configuration for depth sensitive fluorescence measurements in turbid media
Author(s): Yi Hong Ong; Quan Liu
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Paper Abstract

We have developed a novel cone shell illumination and detection configurations using combination of axicon lenses for depth sensitive fluorescence spectroscopy. The probe was demonstrated experimentally to be able to selectively detecting fluorescence from different depths from a two-layered turbid agar phantom. In addition to enhanced contrast of subsurface fluorescence measurement as compared to a conventional cone configuration implemented by a microscope objective lens, the axicon lenses based setup eliminated the need of moving the objective lens up or down to achieve depth sensitive measurements, which effectively improves the consistency of optical coupling thus would be preferred in a clinical setting.

Paper Details

Date Published: 4 March 2014
PDF: 5 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 89260J (4 March 2014); doi: 10.1117/12.2038834
Show Author Affiliations
Yi Hong Ong, Nanyang Technological Univ. (Singapore)
Quan Liu, Nanyang Technological Univ. (Singapore)


Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong; Guillermo J. Tearney; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory; Justus F. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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