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Proceedings Paper

Brain metastasis detection by resonant Raman optical biopsy method
Author(s): Yan Zhou; Cheng-hui Liu; Gangge Cheng; Lixin Zhou; Chunyuan Zhang; Yang Pu; Zhongwu Li; Yulong Liu; Qingbo Li; Wei Wang; Robert R. Alfano
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Paper Abstract

Resonant Raman (RR) spectroscopy provides an effective way to enhance Raman signal from particular bonds associated with key molecules due to changes on a molecular level. In this study, RR is used for detection of human brain metastases of five kinds of primary organs of lung, breast, kidney, rectal and orbital in ex-vivo. The RR spectra of brain metastases cancerous tissues were measured and compared with those of normal brain tissues and the corresponding primary cancer tissues. The differences of five types of brain metastases tissues in key bio-components of carotene, tryptophan, lactate, alanine and methyl/methylene group were investigated. The SVM-KNN classifier was used to categorize a set of RR spectra data of brain metastasis of lung cancerous tissues from normal brain tissue, yielding diagnostic sensitivity and specificity at 100% and 75%, respectively. The RR spectroscopy may provide new moleculebased optical probe tools for diagnosis and classification of brain metastatic of cancers.

Paper Details

Date Published: 17 March 2014
PDF: 6 pages
Proc. SPIE 8940, Optical Biopsy XII, 89400C (17 March 2014); doi: 10.1117/12.2038731
Show Author Affiliations
Yan Zhou, The General Hospital of the Air Force, PLA (China)
Cheng-hui Liu, The City College of the City Univ. of New York (United States)
Gangge Cheng, The General Hospital of the Air Force, PLA (China)
Lixin Zhou, Beijing Cancer Hospital (China)
Chunyuan Zhang, The City Univ. of New York (United States)
Yang Pu, The City College of the City Univ. of New York (United States)
Zhongwu Li, Beijing Cancer Hospital (China)
Yulong Liu, Institute of Physics (China)
Qingbo Li, Beihang Univ. (China)
Wei Wang, Beihang Univ. (China)
Robert R. Alfano, The City College of the City Univ. of New York (United States)


Published in SPIE Proceedings Vol. 8940:
Optical Biopsy XII
Robert R. Alfano; Stavros G. Demos, Editor(s)

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