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Proceedings Paper

Tumor margin detection using optical biopsy techniques
Author(s): Yan Zhou; Cheng-hui Liu; Jiyou Li; Zhongwu Li; Lixin Zhou; Ke Chen; Yang Pu; Yong He; Ke Zhu; Qingbo Li; Robert R. Alfano
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Paper Abstract

The aim of this study is to use the Resonance Raman (RR) and fluorescence spectroscopic technique for tumor margin detection with high accuracy based on native molecular fingerprints of breast and gastrointestinal (GI) tissues. This tumor margins detection method utilizes advantages of RR spectroscopic technique in situ and in real-time to diagnose tumor changes providing powerful tools for clinical guiding intraoperative margin assessments and postoperative treatments. The tumor margin detection procedures by RR spectroscopy were taken by scanning lesion from center or around tumor region in ex-vivo to find the changes in cancerous tissues with the rim of normal tissues using the native molecular fingerprints. The specimens used to analyze tumor margins include breast and GI carcinoma and normal tissues. The sharp margin of the tumor was found by the changes of RR spectral peaks within 2 mm distance. The result was verified using fluorescence spectra with 300 nm, 320 nm and 340 nm excitation, in a typical specimen of gastric cancerous tissue within a positive margin in comparison with normal gastric tissues. This study demonstrates the potential of RR and fluorescence spectroscopy as new approaches with labeling free to determine the intraoperative margin assessment.

Paper Details

Date Published: 17 March 2014
PDF: 5 pages
Proc. SPIE 8940, Optical Biopsy XII, 894014 (17 March 2014); doi: 10.1117/12.2038723
Show Author Affiliations
Yan Zhou, The General Hospital of the Air Force, PLA (China)
Cheng-hui Liu, The City College of the City Univ. New York (United States)
Jiyou Li, Beijing Cancer Hospital (China)
Zhongwu Li, Beijing Cancer Hospital (China)
Lixin Zhou, Beijing Cancer Hospital (China)
Ke Chen, Beijing Cancer Hospital (China)
Yang Pu, The City College of the City Univ. of New York (United States)
Yong He, Beijing Normal Univ. (China)
Ke Zhu, Institute of Physics (China)
Qingbo Li, Beihang Univ. (China)
Robert R. Alfano, The City College of the City Univ. of New York (United States)

Published in SPIE Proceedings Vol. 8940:
Optical Biopsy XII
Robert R. Alfano; Stavros G. Demos, Editor(s)

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