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Proceedings Paper

Tryptophan content for monitoring breast cancer cell aggressiveness by native fluorescence spectroscopy
Author(s): Lin Zhang; Yang Pu; Jianpeng Xue; Sebastião Pratavieira; Baogang Xu; Samuel Achilefu; R. R. Alfano
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Paper Abstract

This study shows tryptophan as the key native marker in cells to determine the level of aggressive cancer in breast cell lines using native fluorescence spectroscopy. An algorithm based on the ratio of tryptophan fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. The higher the ratio is, the more aggressive the tumor towards metastasis.

Paper Details

Date Published: 17 March 2014
PDF: 9 pages
Proc. SPIE 8940, Optical Biopsy XII, 894015 (17 March 2014); doi: 10.1117/12.2038712
Show Author Affiliations
Lin Zhang, The City College of the City Univ. of New York (United States)
Yang Pu, The City College of the City Univ. of New York (United States)
Jianpeng Xue, Washington Univ. in St. Louis, School of Medicine (United States)
Sebastião Pratavieira, The City College of the City Univ. of New York (United States)
Univ. de São Paulo (Brazil)
Baogang Xu, Washington Univ. in St. Louis, School of Medicine (United States)
Samuel Achilefu, Washington Univ. in St. Louis, School of Medicine (United States)
R. R. Alfano, The City College of the City Univ. of New York (United States)


Published in SPIE Proceedings Vol. 8940:
Optical Biopsy XII
Robert R. Alfano; Stavros G. Demos, Editor(s)

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