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Proceedings Paper

Model-based optical coherence elastography using acoustic radiation force
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Paper Abstract

Acoustic Radiation Force (ARF) stimulation is actively used in ultrasound elastography to estimate mechanical properties of tissue. Compared with ultrasound imaging, OCT provides advantage in both spatial resolution and signal-to-noise ratio. Therefore, a combination of ARF and OCT technologies can provide a unique opportunity to measure viscoelastic properties of tissue, especially when the use of high intensity radiation pressure is limited for safety reasons. In this presentation we discuss a newly developed theoretical model of the deformation of a layered viscoelastic medium in response to an acoustic radiation force of short duration. An acoustic impulse was considered as an axisymmetric force generated on the upper surface of the medium. An analytical solution of this problem was obtained using the Hankel transform in frequency domain. It was demonstrated that layers at different depths introduce different frequency responses. To verify the developed model, experiments were performed using tissue-simulating, inhomogeneous phantoms of varying mechanical properties. The Young’s modulus of the phantoms was varied from 5 to 50 kPa. A single-element focused ultrasound transducer (3.5 MHz) was used to apply the radiation force with various durations on the surface of phantoms. Displacements on the phantom surface were measured using a phase-sensitive OCT at 25 kHz repetition frequency. The experimental results were in good agreement with the modeling results. Therefore, the proposed theoretical model can be used to reconstruct the mechanical properties of tissue based on ARF/OCT measurements.

Paper Details

Date Published: 26 February 2014
PDF: 8 pages
Proc. SPIE 8946, Optical Elastography and Tissue Biomechanics, 89460T (26 February 2014); doi: 10.1117/12.2038584
Show Author Affiliations
Salavat Aglyamov, The Univ. of Texas at Austin (United States)
Shang Wang, Univ. of Houston (United States)
Andrei Karpiouk, The Univ. of Texas at Austin (United States)
Jiasong Li, Univ. of Houston (United States)
Stanislav Emelianov, The Univ. of Texas at Austin (United States)
Kirill V. Larin, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 8946:
Optical Elastography and Tissue Biomechanics
Kirill V. Larin; David D. Sampson, Editor(s)

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