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Proceedings Paper

Association phenothiazine and laser on growth of C. tropicalis fluconazole-resistant
Author(s): Rafael Araújo Gomes Júnior; Susana C. P. S. de Oliveira; Juliana S. C. Monteiro; Gustavo M. P. Santos; Fernando J. P. Sampaio; Maria F. M. Gesteira; Fátima A. A. Zanin; Aldo Brugnera; Antônio Luiz B. Pinheiro; Marcos A. Vannier-Santos
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Paper Abstract

Candidiasis is caused by Candida species found on the skin, gastrointestinal tract and mucous cavities of the humans and may be acute, chronic, localized or systemic. Alhough C. albicans is the species most often identified as responsible for this type of infection C. Tropicalis has been considered an emerging cause. The effect of the association of phenothiazine - PTZ and laser on fluconazole-resistant C.tropicalis growth was tested. 2.5 x 106 CFU/mL 100mg/mL of phenothiazine with the pre-irradiation time of 10 min were irradiated with laser light (660 nm; 4.8 and 12 J/cm2 (L1 and L2 respectively) 40 mW) followed by incubation in RPMI for 24h. The following conditions were tested: control (control), laser (L1 and L2), phenothiazine (F1 and F2), and PACT (F1L1 and F2L2). Statistically significant diferences were seen between groups (L-F +) and (F + L +) for both conditions of the laser, with a growth inhibition of the yeast around 67 and 51%, respectively, however, when using only the laser there was an increase of 18% in the survival of these cells. PACT's efficacy on fluconazole-resistant C. tropicalis depended on both the time of pre-irradiation and concentration of the PTZ.

Paper Details

Date Published: 18 February 2014
PDF: 5 pages
Proc. SPIE 8932, Mechanisms for Low-Light Therapy IX, 89320G (18 February 2014); doi: 10.1117/12.2038566
Show Author Affiliations
Rafael Araújo Gomes Júnior, Fundação Oswaldo Cruz (Brazil)
Susana C. P. S. de Oliveira, Univ. Federal da Bahia (Brazil)
National Institute of Optics and Photonics (Brazil)
Juliana S. C. Monteiro, Univ. Federal da Bahia (Brazil)
National Institute of Optics and Photonics (Brazil)
Univ. Estadual de Feira de Santana (Brazil)
Gustavo M. P. Santos, Fundação Oswaldo Cruz (Brazil)
Fernando J. P. Sampaio, Univ. Federal da Bahia (Brazil)
National Institute of Optics and Photonics (Brazil)
Maria F. M. Gesteira, Univ. Federal da Bahia (Brazil)
National Institute of Optics and Photonics (Brazil)
Fátima A. A. Zanin, Univ. Federal da Bahia (Brazil)
National Institute of Optics and Photonics (Brazil)
Brugnera & Zanin Institute (Brazil)
Aldo Brugnera, Univ. Federal da Bahia (Brazil)
National Institute of Optics and Photonics (Brazil)
Brugnera & Zanin Institute (Brazil)
Antônio Luiz B. Pinheiro, Univ. Federal da Bahia (Brazil)
National Institute of Optics and Photonics (Brazil)
Brugnera & Zanin Institute (Brazil)
Marcos A. Vannier-Santos, Fundação Oswaldo Cruz (Brazil)


Published in SPIE Proceedings Vol. 8932:
Mechanisms for Low-Light Therapy IX
Michael R. Hamblin; James D. Carroll; Praveen Arany, Editor(s)

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