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Proceedings Paper

Optical coherence tomography detection of shear wave propagation in MCF7 cell modules
Author(s): Marjan Razani; Adrian Mariampillai; Elizabeth S. L. Berndl; Tim-Rasmus Kiehl; Victor X. D. Yang; Michael C. Kolios
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Paper Abstract

In this work, we explored the potential of measuring shear wave propagation using Optical Coherence Elastography (OCE) in MCF7 cell modules (comprised of MCF7 cells and collagen) and based on a swept-source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs, synchronized with an OCT swept source wavelength sweep imaging system. Acoustic radiation force was applied to the MCF7 cell constructs. Differential OCT phase maps, measured with and without the acoustic radiation force, demonstrate microscopic displacement generated by shear wave propagation in these modules. The OCT phase maps are acquired with a swept-source OCT (SS-OCT) system. We also calculated the tissue mechanical properties based on the propagating shear waves in the MCF7 + collagen phantoms using the Acoustic Radiation Force (ARF) of an ultrasound transducer, and measured the shear wave speed with the OCT phase maps. This method lays the foundation for future studies of mechanical property measurements of breast cancer structures, with applications in the study of breast cancer pathologies.

Paper Details

Date Published: 26 February 2014
PDF: 7 pages
Proc. SPIE 8946, Optical Elastography and Tissue Biomechanics, 894610 (26 February 2014); doi: 10.1117/12.2038428
Show Author Affiliations
Marjan Razani, Ryerson Univ. (Canada)
Adrian Mariampillai, Ryerson Univ. (Canada)
Elizabeth S. L. Berndl, Ryerson Univ. (Canada)
Tim-Rasmus Kiehl, Univ. Health Network (Canada)
Univ. of Toronto (Canada)
Victor X. D. Yang, Ryerson Univ. (Canada)
Univ. of Toronto (Canada)
Michael C. Kolios, Ryerson Univ. (Canada)

Published in SPIE Proceedings Vol. 8946:
Optical Elastography and Tissue Biomechanics
Kirill V. Larin; David D. Sampson, Editor(s)

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