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Proceedings Paper

In vivo stepwise multi-photon activation fluorescence imaging of melanin in human skin
Author(s): Zhenhua Lai; Zetong Gu; Saleh Abbas; Jared Lowe; Heidy Sierra; Milind Rajadhyaksha; Charles DiMarzio
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Paper Abstract

The stepwise multi-photon activated fluorescence (SMPAF) of melanin is a low cost and reliable method of detecting melanin because the activation and excitation can be a continuous-wave (CW) mode near infrared (NIR) laser. Our previous work has demonstrated the melanin SMPAF images in sepia melanin, mouse hair, and mouse skin. In this study, we show the feasibility of using SMPAF to detect melanin in vivo. in vivo melanin SMPAF images of normal skin and benign nevus are demonstrated. SMPAF images add specificity for melanin detection than MPFM images and CRM images. Melanin SMPAF is a promising technology to enable early detection of melanoma for dermatologists.

Paper Details

Date Published: 12 March 2014
PDF: 4 pages
Proc. SPIE 8949, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXI, 894919 (12 March 2014); doi: 10.1117/12.2038310
Show Author Affiliations
Zhenhua Lai, Northeastern Univ. (United States)
Bernard M. Gordon Ctr. for Subsurface Sensing and Imaging System (United States)
Zetong Gu, Northeastern Univ. (United States)
Bernard M. Gordon Ctr. for Subsurface Sensing and Imaging System (United States)
Saleh Abbas, Northeastern Univ. (United States)
Jared Lowe, Northeastern Univ. (United States)
Heidy Sierra, Memorial and Sloan-Kettering Cancer Ctr. (United States)
Milind Rajadhyaksha, Memorial and Sloan-Kettering Cancer Ctr. (United States)
Charles DiMarzio, Northeastern Univ. (United States)
Bernard M. Gordon Ctr. for Subsurface Sensing and Imaging System (United States)


Published in SPIE Proceedings Vol. 8949:
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXI
Thomas G. Brown; Carol J. Cogswell; Tony Wilson, Editor(s)

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