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Proceedings Paper

Multidentate oligomeric ligands to enhance the biocompatibility of iron oxide and other metal nanoparticles
Author(s): Wentao Wang; Goutam Palui; Xin Ji; Fadi Aldeek; Hedi Mattoussi
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Paper Abstract

We prepared a set of multi-coordinating and reactive amphiphilic polymer ligands and used them for surface-functionalizing magnetic iron oxide nanoparticles. The amphiphilic oligomers were prepared by coupling (via one step nucleophilic addition) several dopamine anchoring groups, polyethylene glycol moieties and reactive groups onto a poly(isobutylene-alt-maleic anhydride) chain. The availability of several anchoring groups in the same ligand greatly enhances the ligand affinity to the nanoparticle surfaces, via multiplecoordination, while the hydrophilic and reactive groups promote colloidal stability in buffer media and allow subsequent conjugation to target biomolecules. The hydrophilic nanoparticles capped with these polymers maintain compact size and exhibit great long term colloidal stability.

Paper Details

Date Published: 24 March 2014
PDF: 8 pages
Proc. SPIE 8955, Colloidal Nanoparticles for Biomedical Applications IX, 89550B (24 March 2014); doi: 10.1117/12.2038307
Show Author Affiliations
Wentao Wang, The Florida State Univ. (United States)
Goutam Palui, The Florida State Univ (United States)
Xin Ji, The Florida State Univ. (United States)
Fadi Aldeek, The Florida State Univ. (United States)
Hedi Mattoussi, The Florida State Univ. (United States)

Published in SPIE Proceedings Vol. 8955:
Colloidal Nanoparticles for Biomedical Applications IX
Wolfgang J. Parak; Marek Osinski; Kenji I. Yamamoto, Editor(s)

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