Share Email Print

Proceedings Paper

Application of ball-lens hollow fiber Raman probe for studying anorectal prolapse
Author(s): Bibin Bintang Andriana; Akinori Taketani; C. Linda R. Soeratman; Mika Ishigaki; Yasuhiro Maeda; Masanori Sawa; Hidetoshi Sato
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Our Raman probe that is called as ball-lens hollow fiber Raman probe (BHRP) had been proved possessing capability to detect the biochemical alteration within biological tissue. Whether BHRP has high capability and sensitivity in diagnosing the biochemical changing of tissue or not, mouse's normal rectal and anorectal prolapse (AP) were decided to be used as a model for this non invasive method. This AP is azoxymethane and DSS-induced mouse’s anorectal prolapse. Main outcome of BHRP will be potential for non-invasive method in tumor diagnosing. BHRP spectra obtained were a high quality and allowed analysis of their differences between normal rectal (control group) and AP. After spectral acquisition and comparison with corresponding images of hematoxylin/eosinstained section observation used to make the histopathologic diagnosing, BHRP detected some differences within the region of moiety of DNA, protein (i.e. collagen) and lipid, then following with the alteration of symmetric P=O stretching vibration compared with the normal rectal tissue. BHRP discriminate normal tissue and AP in the real-time.

Paper Details

Date Published: 20 February 2014
PDF: 11 pages
Proc. SPIE 8938, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV, 893816 (20 February 2014); doi: 10.1117/12.2037884
Show Author Affiliations
Bibin Bintang Andriana, Kwansei Gakuin Univ. (Japan)
Akinori Taketani, Kwansei Gakuin Univ. (Japan)
C. Linda R. Soeratman, The Univ. of Tokyo (Japan)
Mika Ishigaki, Kwansei Gakuin Univ. (Japan)
Yasuhiro Maeda, Kwansei Gakuin Univ. (Japan)
Masanori Sawa, Kwansei Gakuin Univ. (Japan)
Hidetoshi Sato, Kwansei Gakuin Univ. (Japan)

Published in SPIE Proceedings Vol. 8938:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV
Israel Gannot, Editor(s)

© SPIE. Terms of Use
Back to Top