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Proceedings Paper

Elastography methods applicable to the eye
Author(s): Altaf A. Khan; Soledad M. Cortina; Wallace Chamon; Thomas J. Royston
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Paper Abstract

Elastography is the mapping of tissues and cells by their respective mechanical properties, such as elasticity and viscosity. Our interest primarily lies in the human eye. Combining Scanning Laser Doppler Vibrometry (SLDV) with geometrically focused mechanical vibratory excitations of the cornea, it is possible to reconstruct these mechanical properties of the cornea. Experiments were conducted on phantom corneas as well as excised donor human corneas to test feasibility and derive a method of modeling. Finite element analysis was used to recreate the phantom studies and corroborate with the experimental data. Results are in close agreement. To further expand the study, lamb eyes were used in MR Elastography studies. 3D wave reconstruction was created and elastography maps were obtained. With MR Elastography, it would be possible to noninvasively measure mechanical properties of anatomical features not visible to SLDV, such as the lens and retina. Future plans include creating a more robust finite element model, improving the SLDV method for in-vivo application, and continuing experiments with MR Elastography.

Paper Details

Date Published: 26 February 2014
PDF: 8 pages
Proc. SPIE 8946, Optical Elastography and Tissue Biomechanics, 89460B (26 February 2014); doi: 10.1117/12.2037364
Show Author Affiliations
Altaf A. Khan, Univ. of Illinois at Chicago (United States)
Soledad M. Cortina, Univ. of Illinois at Chicago (United States)
Wallace Chamon, Univ. of Illinois at Chicago (United States)
Univ. Federal de São Paulo (Brazil)
Thomas J. Royston, Univ. of Illinois at Chicago (United States)

Published in SPIE Proceedings Vol. 8946:
Optical Elastography and Tissue Biomechanics
Kirill V. Larin; David D. Sampson, Editor(s)

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