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Proceedings Paper

Photo-excitation of electrons in cytochrome c oxidase as a theory of the mechanism of the increase of ATP production in mitochondria by laser therapy
Author(s): Andrzej Zielke
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Paper Abstract

The hypothesis explains the molecular basis for restoring mitochondrial function by laser therapy. It also explains how laser therapy reverses both excessive oxidation (lack of NADH/FADH2) and excessive reduction (lack of O2) states of cytochrome c oxidase complex. It is proposed that photons interact with heme molecules of cytochrome c oxidase. A molecule of heme contains a porphyrin ring and an atom of iron in the center. The iron atom (Fe) can switch oxidation states back and forth between ferrous (Fe2+) and ferric (Fe3+) by accepting or releasing an electron. The porphyrin ring is a complex aromatic molecule that has 26 pi electrons which are “delocalized”, spinning in the carbon rings creating a resonating electromagnetic cloud. Photons with similar wavelengths are absorbed by the cloud increasing its energy. The energy is then passed on to the centrally located atom of iron existing in a reduced state (Fe2+). The electrons on the orbits of the iron atom accept this electromagnetic energy, and change orbitals to a higher energetic level. If the energy is sufficient, electrons leave the atom entirely. If this occurs, Fe2+ become oxidized to Fe3+ releasing electrons, thus restoring electron flow and the production of ATP. At the same time, electrons freed from complex IV may have sufficient energy to be picked by NAD+/FADH and re-enter the chain at the complex I or II amplifying the flow of electrons.

Paper Details

Date Published: 18 February 2014
PDF: 6 pages
Proc. SPIE 8932, Mechanisms for Low-Light Therapy IX, 893204 (18 February 2014); doi: 10.1117/12.2037141
Show Author Affiliations
Andrzej Zielke, Medical Frontiers, LLC (United States)

Published in SPIE Proceedings Vol. 8932:
Mechanisms for Low-Light Therapy IX
Michael R. Hamblin; James D. Carroll; Praveen Arany, Editor(s)

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