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Proceedings Paper

Imaging infrared spectroscopy for fixation-free liver tumor detection
Author(s): James V. Coe; Zhaomin Chen; Ran Li; Ryan Butke; Barrie Miller; Charles L. Hitchcock; Heather C. Allen; Stephen P. Povoski; Edward W. Martin
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Paper Abstract

Infrared (IR) imaging spectroscopy of human liver tissue slices has been used to identify and characterize a liver metastasis of breast origin (mucinous carcinoma) which was surgically removed from a consenting patient and frozen without formalin fixation or dehydration procedures, so that lipids and water remain in the tissues. Previously, a set of IR metrics was determined for tumors in fixation-free liver tissues facilitating a k-means cluster analysis differentiating tumor from nontumor. Different and more in depth aspects of these results are examined in this work including three metric color imaging, differencing for lipid identification, and a new technique to simultaneously fit band lineshapes and their 2nd derivatives in order to better characterize protein changes.

Paper Details

Date Published: 4 March 2014
PDF: 6 pages
Proc. SPIE 8947, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, 89470B (4 March 2014); doi: 10.1117/12.2037107
Show Author Affiliations
James V. Coe, The Ohio State Univ. (United States)
Zhaomin Chen, The Ohio State Univ. (United States)
Ran Li, The Ohio State Univ. (United States)
Ryan Butke, The Ohio State Univ. (United States)
Barrie Miller, The Ohio State Univ. (United States)
Charles L. Hitchcock, The Ohio State Univ. (United States)
Heather C. Allen, The Ohio State Univ. (United States)
Stephen P. Povoski, The Ohio State Univ. (United States)
Edward W. Martin, The Ohio State Univ. (United States)


Published in SPIE Proceedings Vol. 8947:
Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII
Daniel L. Farkas; Dan V. Nicolau; Robert C. Leif, Editor(s)

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