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Proceedings Paper

Irradiation with EMOLED improves the healing process in superficial skin wounds
Author(s): Riccardo Cicchi; Francesca Rossi; Francesca Tatini; Stefano Bacci; Gaetano De Siena; Domenico Alfieri; Roberto Pini; Francesco S. Pavone
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Paper Abstract

A faster healing process was observed in superficial skin wounds after irradiation with the EMOLED photocoagulator. The instrument consists of a compact handheld photocoagulation device, useful for inducing coagulation in superficial abrasions. The illumination is provided by a high power blue LED. Blue light is selectively absorbed by haemoglobin and converted into heat through a photothermal effect. In this study, 10 Sprague Dawley rats were mechanically abraded in four regions of their back: two regions were used as a control and the other two were treated with EMOLED. The photothermal effect was monitored by an infrared thermocamera in order to avoid accidental thermal damage. Visual observations, histopathological analysis and non-linear microscopic imaging performed after 8 days from the treatment showed no adverse reactions and no thermal damage in both treated areas and surrounding tissues. Moreover, a faster healing process and a better-recovered morphology was evidenced in the treated tissue with respect to the untreated tissue. Compared to the control regions, a reduced inflammatory response, a higher collagen content, and a skin morphology more similar to normal skin were observed in the treated regions. Collagen organization in the two regions was characterized using image pattern analysis algorithms on SHG images, demonstrating a fully recovered aspect of dermis as well as a faster neocollagenesis in the treated regions. This study demonstrates that the selective photothermal effect we used for inducing immediate coagulation in superficial wounds is associated to a minimal inflammatory response, which provides reduced recovery times and improved healing process.

Paper Details

Date Published: 4 March 2014
PDF: 6 pages
Proc. SPIE 8926, Photonic Therapeutics and Diagnostics X, 892604 (4 March 2014); doi: 10.1117/12.2037014
Show Author Affiliations
Riccardo Cicchi, Istituto Nazionale di Ottica, CNR (Italy)
European Lab. for Nonlinear Spectroscopy (Italy)
Francesca Rossi, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
Francesca Tatini, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
Stefano Bacci, Univ. degli Studi di Firenze (Italy)
Gaetano De Siena, Univ. degli Studi di Firenze (Italy)
Domenico Alfieri, Light4Tech Firenze S.r.l. (Italy)
Roberto Pini, Istituto di Fisica Applicata Nello Carrara, CNR (Italy)
Francesco S. Pavone, Istituto Nazionale di Ottica, CNR (Italy)
European Lab. for Non-linear Spectroscopy (Italy)
Univ. degli Studi di Firenze (Italy)


Published in SPIE Proceedings Vol. 8926:
Photonic Therapeutics and Diagnostics X
Bernard Choi; Hyun Wook Kang; Brian J. F. Wong; Guillermo J. Tearney; Andreas Mandelis; Nikiforos Kollias; Kenton W. Gregory; Justus F. Ilgner; Haishan Zeng; Laura Marcu, Editor(s)

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