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Proceedings Paper

Lipid-modified dendrimers as a tool for the design of nanoparticle-based multimodal MRI contrast agents
Author(s): Adriano Boni; Mauro Gemmi; Claudia Innocenti; Giuseppe Bardi; Alice Bertero; Giovanni Signore; Angelo Bifone
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Paper Abstract

A fast and easy method for water transfer of iron oxide nanoparticle based on the hydrophobic interaction of oleic acid coated nanoparticles with the amphiphilic PAMAM-C12 dendrimer is described. The process may be conveniently performed in water and yields nanoparticles with good size distribution, diameter modulation and high crystallinity. The nanoparticles have been functionalized with gadolinium ions to obtain T1/T2 dual mode contrast agents. Furthermore, the possibility to deliver and release lipophilic drugs was investigated.

Paper Details

Date Published: 24 March 2014
PDF: 11 pages
Proc. SPIE 8955, Colloidal Nanoparticles for Biomedical Applications IX, 895502 (24 March 2014); doi: 10.1117/12.2036748
Show Author Affiliations
Adriano Boni, Istituto Italiano di Tecnologia (Italy)
Mauro Gemmi, Istituto Italiano di Tecnologia (Italy)
Claudia Innocenti, Univ. degli Studi di Firenze (Italy)
Giuseppe Bardi, Istituto Italiano di Tecnologia (Italy)
Alice Bertero, Istituto Italiano di Tecnologia (Italy)
Giovanni Signore, Istituto Italiano di Tecnologia (Italy)
Angelo Bifone, Istituto Italiano di Tecnologia (Italy)

Published in SPIE Proceedings Vol. 8955:
Colloidal Nanoparticles for Biomedical Applications IX
Wolfgang J. Parak; Marek Osinski; Kenji I. Yamamoto, Editor(s)

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