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Proceedings Paper

Selenide and telluride glasses for mid-infrared bio-sensing
Author(s): Shuo Cui; Radwan Chahal; Yaroslav Shpotyuk; Catherine Boussard; Jacques Lucas; Frederic Charpentier; Hugues Tariel; Olivier Loréal; Virginie Nazabal; Olivier Sire; Valérie Monbet; Zhiyong Yang; Pierre Lucas; Bruno Bureau
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Paper Abstract

Fiber Evanescent Wave Spectroscopy (FEWS) is an efficient way to collect optical spectra in situ, in real time and even, hopefully, in vivo. Thanks to selenide glass fibers, it is possible to get such spectra over the whole mid-infrared range from 2 to 12 μm. This working window gives access to the fundamental vibration band of most of biological molecules. Moreover selenide glasses are stable and easy to handle, and it is possible to shape the fiber and create a tapered sensing head to drastically increase the sensitivity. Within the past decades, numerous multi-disciplinary studies have been conducted in collaboration with the City Hospital of Rennes. Clinical trials have provided very promising results in biology and medicine which have led to the creation in 2011 of the DIAFIR Company dedicated to the commercialization of fiber-based infrared biosensors. In addition, new glasses based on tellurium only have been recently developed, initially in the framework of the Darwin mission led by the European Space Agency (ESA). These glasses transmit light further into the far-infrared and could also be very useful for medical applications in the near future. Indeed, they permit to reach the vibrational bands of biomolecules laying from 12 to 16 μm where selenide glasses do not transmit light anymore. However, while Se is a very good glass former, telluride glasses tend to crystallize easily due to the metallic nature of Te bonds. Hence, further work is under way to stabilize the glass composition for fibers drawing and to lower the optical losses for improving their sensitivity as bio-sensors.

Paper Details

Date Published: 20 February 2014
PDF: 9 pages
Proc. SPIE 8938, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV, 893805 (20 February 2014); doi: 10.1117/12.2036734
Show Author Affiliations
Shuo Cui, Univ. de Rennes 1 (France)
Zhejiang Univ. (China)
Radwan Chahal, Univ. de Rennes 1 (France)
Yaroslav Shpotyuk, Univ. de Rennes 1 (France)
Catherine Boussard, Univ. de Rennes 1 (France)
Jacques Lucas, Univ. de Rennes 1 (France)
Frederic Charpentier, DIAFIR (France)
Hugues Tariel, DIAFIR (France)
Olivier Loréal, Univ. de Rennes 1 (France)
Virginie Nazabal, Univ. de Rennes 1 (France)
Olivier Sire, Univ. Européenne de Bretagne (France)
Valérie Monbet, Univ. Européenne de Bretagne (France)
Zhiyong Yang, The Univ. of Arizona (United States)
Australian National Univ. (Australia)
Pierre Lucas, The Univ. of Arizona (United States)
Bruno Bureau, Univ. de Rennes 1 (France)

Published in SPIE Proceedings Vol. 8938:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV
Israel Gannot, Editor(s)

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