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Proceedings Paper

UV transmittance during the crosslinking procedure: tunable treatment
Author(s): Victor A. C. Lincoln; Marcio M. Mello; Liliane Ventura
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Paper Abstract

The transmittance of UVA light through the in vitro human cornea over the thickness of 400um during the corneal collagen cross-linking procedure has been measured using an optical fiber (600 μm core diameter) fixed just before the cornea and attached to Spectrophotometer. The 10 corneas, (average of 6 days post-mortem) were washed with saline and cross-linked with the currently used protocol. To enhance absorption of UV radiation, Riboflavin solution (0.1% and 400 mOsm) was applied prior to and during exposure. The UVA beam - 365nm ± 5nm at 3mW/cm2 ± 0.003mW/cm2 - was focused directly onto the corneal stroma. The measured average transmittance of the cornea without Riboflavin was 64.1%. Preceding the irradiation but after 6 applications of Riboflavin at 5min intervals (total of 30min) transmittance decreased to 21.1%. The 30min of irradiation were then accompanied by an additional 6 applications of Riboflavin at 5min intervals (for a total of treatment time of 1h), resulting in a further decrease in transmittance to 12.2%, which is in agreement with current literature. The average transmittance in terms of energy during the 30 minutes irradiation procedure fluctuated from 0.63 to 0.37 mW/cm2. These results indicate different levels of UV transmittance during treatment, leading to consider a new personalized treatment with tunable UV power irradiation.

Paper Details

Date Published: 28 February 2014
PDF: 6 pages
Proc. SPIE 8930, Ophthalmic Technologies XXIV, 89301F (28 February 2014); doi: 10.1117/12.2036641
Show Author Affiliations
Victor A. C. Lincoln, Univ. de São Paulo (Brazil)
Marcio M. Mello, Univ. de São Paulo (Brazil)
Liliane Ventura, Univ. de São Paulo (Brazil)

Published in SPIE Proceedings Vol. 8930:
Ophthalmic Technologies XXIV
Fabrice Manns; Per G. Söderberg; Arthur Ho, Editor(s)

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