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Proceedings Paper

Comparison of clinical effectiveness of laser acupuncture and amitriptyline in diabetic peripheral neuropathy (DPN): a sham controlled randomized clinical trial
Author(s): Imran Hassan Khan; Shahzad Anwar; Asif Hanif; Muhammad Ayub; Arsalan Jamil Raja
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Paper Abstract

Background: Painful neuropathy is a very common complication in diabetic patients. Various treatment strategies like manual therapies, conservative management, drug therapy and exercise have been opted for this problem. Studies have shown clinical effectiveness of laser acupuncture as well. On the other hand, Amitryptaline is also a commonly used treatment for this disease. We aim to compare the efficacy of both treatments. Objective: To assess the effect of laser acupuncture in patients suffering from painful diabetic neuropathy and its comparison with standard of care. Patients and Method: This study was conducted in Diabetic and Endocrine Management Center (DEMC) Lahore General Hospital, Lahore, Pakistan. A randomized control trial (RCT) was opted and a total of 164 patients were chosen using Non-probability purposive sampling technique. Pain was graded by using a patient friendly Visual Analogue Score (VAS), scoring from 0 to 10. Treatment was done involving organized fortnightly follow ups. Data of all patients was recorded on Performa and was entered and analyzed for descriptive statistics in PASW 18 (IBM®. SPSS). Results: A total of 164 subjects were included in the study who were subdivided into three groups labeled as A, B and C for laser therapy treatment, amitryptaline treatment and controls respectively. The mean age of subjects was 51.54±10.46 in Group A, 49.38±10.56 in Group B and 51.70±11.43 in Group C. The difference of mean ages in all study groups was statistically insignificant (p-value= 0.469). The average pain score in patients who received laser therapy was 5.95±0.91 before treatment, whereas after treatment it was 4.31±0.98. The mean pain score in subjects having Amitryptaline before starting the treatment was 6.87±0.71 and after treatment, it was 6.23±0.98. The mean score for daily life activities in subjects who received laser therapy was 9.562.37 before treatment, while after treatment it was 7.56±1.54. The average score for daily life activities in patients having Amitryptaline before starting the treatment was 9.05±1.93 and after treatment, it was 8.11±1.71. Average depression and anxiety score in patients receiving laser therapy was 9.29±2.28 before treatment, whereas after treatment it was found to be 7.42±1.91. Similarly, the mean depression and anxiety score in patients of Amitryptaline group before starting the treatment was 9.38±2.21 and after treatment, it was 8.38±2.14. Conclusion: The mean score in our study reveals that laser therapy shows better outcomes in improvement of pain relief, depression, anxiety and daily life activities compared to amitryptaline in patients of diabetic neuropathy.

Paper Details

Date Published: 18 February 2014
PDF: 15 pages
Proc. SPIE 8932, Mechanisms for Low-Light Therapy IX, 893210 (18 February 2014); doi: 10.1117/12.2036376
Show Author Affiliations
Imran Hassan Khan, Lahore General Hospital (Pakistan)
Shahzad Anwar, Iffat Anwar Medical Complex Lahore (Pakistan)
Asif Hanif, Post Graduate Medical Institute Lahore (Pakistan)
Muhammad Ayub, Lahore General Hospital (Pakistan)
Arsalan Jamil Raja, Lahore General Hospital (Pakistan)


Published in SPIE Proceedings Vol. 8932:
Mechanisms for Low-Light Therapy IX
Michael R. Hamblin; James D. Carroll; Praveen Arany, Editor(s)

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