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Proceedings Paper

Optimal arrangements of fiber optic probes to enhance the spatial resolution in depth for 3D reflectance diffuse optical tomography with time-resolved measurements performed with fast-gated single-photon avalanche diodes
Author(s): Agathe Puszka; Laura Di Sieno; Alberto Dalla Mora; Antonio Pifferi; Davide Contini; Gianluca Boso; Alberto Tosi; Lionel Hervé; Anne Planat-Chrétien; Anne Koenig; Jean-Marc Dinten
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Paper Abstract

Fiber optic probes with a width limited to a few centimeters can enable diffuse optical tomography (DOT) in intern organs like the prostate or facilitate the measurements on extern organs like the breast or the brain. We have recently shown on 2D tomographic images that time-resolved measurements with a large dynamic range obtained with fast-gated single-photon avalanche diodes (SPADs) could push forward the imaged depth range in a diffusive medium at short source-detector separation compared with conventional non-gated approaches. In this work, we confirm these performances with the first 3D tomographic images reconstructed with such a setup and processed with the Mellin- Laplace transform. More precisely, we investigate the performance of hand-held probes with short interfiber distances in terms of spatial resolution and specifically demonstrate the interest of having a compact probe design featuring small source-detector separations. We compare the spatial resolution obtained with two probes having the same design but different scale factors, the first one featuring only interfiber distances of 15 mm and the second one, 10 mm. We evaluate experimentally the spatial resolution obtained with each probe on the setup with fast-gated SPADs for optical phantoms featuring two absorbing inclusions positioned at different depths and conclude on the potential of short source-detector separations for DOT.

Paper Details

Date Published: 17 February 2014
PDF: 6 pages
Proc. SPIE 8937, Multimodal Biomedical Imaging IX, 89370Z (17 February 2014); doi: 10.1117/12.2036351
Show Author Affiliations
Agathe Puszka, CEA-LETI (France)
Laura Di Sieno, Politecnico di Milano (Italy)
Alberto Dalla Mora, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)
Davide Contini, Politecnico di Milano (Italy)
Gianluca Boso, Politecnico di Milano (Italy)
Alberto Tosi, Politecnico di Milano (Italy)
Lionel Hervé, CEA-LETI (France)
Anne Planat-Chrétien, CEA-LETI (France)
Anne Koenig, CEA-LETI (France)
Jean-Marc Dinten, CEA-LETI (France)

Published in SPIE Proceedings Vol. 8937:
Multimodal Biomedical Imaging IX
Fred S. Azar; Xavier Intes, Editor(s)

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