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Proceedings Paper

A pilot study to compare the cerebral hemodynamics between patients with obstructive sleep apnea syndrome (OSA) and periodic limb movement syndrome (PLMS) during nocturnal sleep with near-infrared spectroscopy (NIRS)
Author(s): Zhongxing Zhang; Maja Schneider; Marco Laures; Ursula Fritschi; Gordana Hügli; Isabella Lehner; Ming Qi; Ramin Khatami
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Paper Abstract

Obstructive sleep apnea syndrome (OSA) and periodic limb movement in sleep syndrome (PLMS) are two common sleep disorders. Previous studies showed that OSA and PLMS share common features, such as increased cardio-vascular risk, both apnea events and limb movements occur periodically, they are usually associated with cortical arousals, and both of them can induce declines in peripheral oxygen saturation measured with pulse oximetry. However, the question whether apnea events and limb movements also show similar characteristics in cerebral hemodynamic and oxygenation has never been addressed. In this pilot study, we will first time compare the cerebral hemodynamic changes induced by apnea events and limb movements in patients with OSA (n=4) and PLMS (n=4) with NIRS. In patients with OSA, we found periodic oscillations in HbO2, HHb, and blood volume induced by apnea/hypopnea events, HbO2 and HHb showed reverse changing trends. By contrast, the periodic oscillations linked to limb movements were only found in HbO2 and blood volume in patients with PLMS. These findings of different cerebral hemodynamics patterns between apnea events and limb movements may indicate different regulations of nervous system between these two sleep disorders.

Paper Details

Date Published: 24 March 2014
PDF: 7 pages
Proc. SPIE 8928, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 892820 (24 March 2014); doi: 10.1117/12.2036264
Show Author Affiliations
Zhongxing Zhang, Clinic Barmelweid (Switzerland)
Univ. Hospital Zurich (Switzerland)
Maja Schneider, Univ. Hospital Zurich (Switzerland)
Marco Laures, Univ. Hospital Zurich (Switzerland)
Ursula Fritschi, Univ. Hospital Zurich (Switzerland)
Gordana Hügli, Univ. Hospital Zurich (Switzerland)
Isabella Lehner, Univ. Hospital Zurich (Switzerland)
Ming Qi, Univ. Hospital Zurich (Switzerland)
Ramin Khatami, Clinic Barmelweid (Switzerland)
Univ. Hospital Zurich (Switzerland)


Published in SPIE Proceedings Vol. 8928:
Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics
Henry Hirschberg; E. Duco Jansen; Samarendra K. Mohanty; Nitish V. Thakor; Qingming Luo; Steen J. Madsen, Editor(s)

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