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Proceedings Paper

Challenges in resonant cavity biosensor design: collection efficiency and specificity
Author(s): Andrea M. Armani; Simin Mehrabani; Victoria Sun; Samantha McBirney; Rasheeda M. Hawk; Eda Gungor; Michele Lee
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Paper Abstract

Optical cavities have successfully demonstrated the ability to detect a wide range of analytes with exquisite sensitivity. However, optimizing other parameters of the system, such as collection efficiency and specificity, have remained elusive. This presentation will discuss some of the recent work in this area, including 3D COMSOL Multiphysics models including mass transfer and binding kinetics of different cavity geometries and covalent attachment methods for a wide range of biological and synthetic moieties. A few representative experimental demonstrations will also be presented.

Paper Details

Date Published: 4 March 2014
PDF: 8 pages
Proc. SPIE 8960, Laser Resonators, Microresonators, and Beam Control XVI, 89600F (4 March 2014); doi: 10.1117/12.2035555
Show Author Affiliations
Andrea M. Armani, The Univ. of Southern California (United States)
Simin Mehrabani, The Univ. of Southern California (United States)
Victoria Sun, The Univ. of Southern California (United States)
Samantha McBirney, The Univ. of Southern California (United States)
Rasheeda M. Hawk, The Univ. of Southern California (United States)
Eda Gungor, The Univ. of Southern California (United States)
Michele Lee, The Univ. of Southern California (United States)


Published in SPIE Proceedings Vol. 8960:
Laser Resonators, Microresonators, and Beam Control XVI
Alexis V. Kudryashov; Alan H. Paxton; Vladimir S. Ilchenko; Lutz Aschke; Kunihiko Washio, Editor(s)

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