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Proceedings Paper

Influence of the laser assisted fabricated 3D porous scaffolds from bioceramoplasts of micron and nano sizes on culture of MMSC
Author(s): I. Shishkovsky; S. Volchkov
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Paper Abstract

The objective of the investigation was to test the biocompatibility of 3D porous biopolymer matrices (tissue-cellular scaffolds), made of biocompatible and bioresorbable polymers (polycarbonate, polyetheretherketone /PEEK/, polycaprolactone), including the materials with biocompatible oxide ceramics additive (TiO2, Al2O3, ZrO2 and hydroxyapatite) of micron and nano sizes, for tissue-engineering purposes. The porous samples were prepared via a layer-by-layer SLS method. The surface microstructures and their roughness were analyzed by the optical microscopy equipped with the cell analysis software. The cellular morphology, proliferative activity and adhesion of the polymeric and ceramopolymeric matrices were the subjects for comparison. The study showed that all the tested materials posessed biocompatible properties. The experimentally estimated cell duplication speed per day turned out to be maximal for polycarbonate (0.279 duplications per day) and for PEEK + Al2O3 = 3:1 group (0.30 dupl/day) against 0.387 dupl/day for the reference sample and 0.270 dupl/day for the group of cells placed close to the pure titanium samples.

Paper Details

Date Published: 28 November 2013
PDF: 8 pages
Proc. SPIE 9065, Fundamentals of Laser-Assisted Micro- and Nanotechnologies 2013, 906515 (28 November 2013); doi: 10.1117/12.2035550
Show Author Affiliations
I. Shishkovsky, P.N. Lebedev Physical Institute (Russian Federation)
Samara State Medical Univ. (Russian Federation)
S. Volchkov, Samara State Medical Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 9065:
Fundamentals of Laser-Assisted Micro- and Nanotechnologies 2013
Vadim P. Veiko; Tigran A. Vartanyan, Editor(s)

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