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Proceedings Paper

Photodynamic response of an endothelial hybridoma cell line using zinc(II) tetrasubstituted phthalocyanines
Author(s): Janet E. Cruse-Sawyer; B. Dixon; David J.H. Roberts; John Griffiths; Stanley B. Brown
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Paper Abstract

The EAhy 926 cell is a hybridoma line derived from human endothelium and A549/8 cells. They display stable endothelial characteristics and may provide an indication of how endothelial cells respond to photodynamic therapy. Cells were grown as monolayers, seeded at a density of 104 cells/35 mm dish, and then incubated with zinc (II) tetrasubstituted phthalocyanines (carboxylated, sulphonated, pyridinium or diethanolamine sulphonamide). After 24 hours, the cells were illuminated with laser light at 680 nm or 692 nm as appropriate. The response to each photosensitizer was evaluated using cell proliferation, clonogenicity, and release of tissue factor.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203449
Show Author Affiliations
Janet E. Cruse-Sawyer, Univ. of Leeds (United Kingdom)
B. Dixon, Univ. of Leeds (United Kingdom)
David J.H. Roberts, Univ. of Leeds (United Kingdom)
John Griffiths, Univ. of Leeds (United Kingdom)
Stanley B. Brown, Univ. of Leeds (United Kingdom)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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