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Proceedings Paper

Localization of zinc(II)-phthalocyanine within implanted tumors after intravenous administration of a liposomal formulation
Author(s): Saskia Duk; Roberta Biolo; William G. Love; Giulio Jori; Peter W. Taylor
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Paper Abstract

The liposomal zinc(II) phthalocyanine (Zn-Pc) formulation CGP55847 was administered intravenously (0.5 mg Zn-Pc/kg) to C57/BL6 mice bearing subcutaneously implanted B16 melanomas or to Swiss mice bearing intramuscularly implanted Ehrlich carcinomas. Tumors were removed 3 or 24 h after dosing, and the Zn-Pc content and intratumoral distribution determined by extraction and quantitative fluorescence microscopy. Localization of the photosensitizer within the tumor mass occurred more rapidly in the highly vascularized Ehrlich carcinoma compared to the less highly vascularized B16 melanoma. Zn-Pc was evident in and around blood vessels 3 but not 24 h after dosing. More Zn-Pc was found in necrotic areas compared to viable tumor tissue; little or no Zn-Pc was detected in the muscle tissue invaded by the Ehrlich carcinoma. At the cellular level, Zn-Pc was associated with membranes and the cytosol but not the nucleus.

Paper Details

Date Published: 1 March 1995
PDF: 4 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203448
Show Author Affiliations
Saskia Duk, CIBA-Geigy Pharmaceuticals (United Kingdom)
Roberta Biolo, Univ. di Padova (Italy)
William G. Love, CIBA-Geigy Pharmaceuticals (United Kingdom)
Giulio Jori, Univ. di Padova (Italy)
Peter W. Taylor, CIBA-Geigy Pharmaceuticals (United Kingdom)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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