Share Email Print
cover

Proceedings Paper

Tissue distribution of liposomal zinc(II)-phthalocyanine in normolipaemic and hyperlipaemic rats following intravenous administration
Author(s): William G. Love; Patrick C.N. Rensen; Ute Isele; Peter W. Taylor
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Liposomal formulations of the photosensitizer zinc(II)-phthalocyanine (Zn-Pc) readily interact with plasma lipoproteins in vitro and in vivo, leading to a redistribution of the photosensitizer amongst the major lipoprotein classes. As lipoprotein binding may facilitate the uptake of lipophilic photosensitizers by proliferating tissues, we have examined the fate of intravenously administered liposomal Zn-Pc in normolipaemic rats and rats rendered hyperlipaemic through dietary intervention. Differences were found in the plasma decay profiles of Zn-Pc and liposomal phospholipid between the two groups of animals.

Paper Details

Date Published: 1 March 1995
PDF: 7 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203447
Show Author Affiliations
William G. Love, CIBA-Geigy Pharmaceuticals (United Kingdom)
CIBA-Geigy Ltd. (Switzerland)
Patrick C.N. Rensen, CIBA-Geigy Pharmaceuticals (United Kingdom)
CIBA-Geigy Ltd. (Switzerland)
Ute Isele, CIBA-Geigy Pharmaceuticals (United Kingdom)
CIBA-Geigy Ltd. (Switzerland)
Peter W. Taylor, CIBA-Geigy Pharmaceuticals (United Kingdom)
CIBA-Geigy Ltd. (Switzerland)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

© SPIE. Terms of Use
Back to Top