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Proceedings Paper

In vivo and in vitro absorption spectrum of disulphonated aluminum phthalocyanine in tumor-bearing mice
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Paper Abstract

The absorption spectrum of disulphonated aluminum phthalocyanine (AlS2Pc) between 650 nm and 695 nm was measured in vivo by means of time-resolved reflectance. The experiments were performed on mice bearing the L1210 leukemia 1, 4, and 7 hr after the i.p. administration of 2.5 mg/kg body weight (b.w.) of AlS2Pc. The absorption peak is centered at 685 nm, red-shifted of 10 - 15 nm with respect to the spectra obtained in solution in various environments. Measurements performed in vitro confirm the results in vivo and seem to suggest that the extracellular environment can cause the shift in the absorption line shape.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203445
Show Author Affiliations
Rinaldo Cubeddu, CEQSE/CNR, Politecnico di Milano (Italy)
Gianfranco L. Canti, Univ. di Milano (Italy)
Antonio Pifferi, CEQSE/CNR, Politecnico di Milano (Italy)
Paola Taroni, CEQSE/CNR, Politecnico di Milano (Italy)
Gianluca Valentini, CEQSE/CNR, Politecnico di Milano (Italy)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting

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