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Proceedings Paper

Photodynamic therapy of malignant mesothelioma of pleura
Author(s): Trond Warloe; Helen Heyerdahl; Qian Peng; J. Hoie; E. Normann; O. Solheim; Johan Moan; Karl-Erik Giercksky
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Paper Abstract

Nine patients with malignant pleural mesothelioma underwent extensive surgery followed by intra-operative photodynamic therapy. Two mg/kg Photofrin was given 48 hours prior to surgery. The thoracic cavity and eventual remaining lung were exposed to 15 - 30 Joules/cm2 of 630 nm laser light. Tumor tissue was analyzed by microscopic photometrical techniques. Five patients with mixed or epithelioid tumors with fluorescence intensity > 100 gray level/pixel seemed to benefit from the given therapy. One patient was free of disease 18 months after treatment. Two patients were treated for metastasis after 12 months with no sign of intrathoracic recurrence. Both are still alive, one without further sign of disease 32 months after initial treatment. Two patients presented generalized disease after 9 and 13 months and intrathoracic recurrence several months later. Two patients with poorly differentiated tumors and 2 patients with moderate to highly differentiated tumors, but with fluorescence intensity < 100 gray level/pixel, presented recurrences after 4 months. PDT-efficiency seems to be predicted by the intensity and distribution of drug-induced fluorescence in tumor tissue. PDT may enhance the possibility to achieve complete local tumor control after excision. Multimodal therapeutic approach of local and systemic disease seems mandatory to further improve survival.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203444
Show Author Affiliations
Trond Warloe, Institute for Cancer Research/The Norwegian Radium Hospital (Norway)
Helen Heyerdahl, Institute for Cancer Research/The Norwegian Radium Hospital (Norway)
Qian Peng, Institute for Cancer Research/The Norwegian Radium Hospital (Norway)
J. Hoie, Institute for Cancer Research/The Norwegian Radium Hospital (Norway)
E. Normann, Institute for Cancer Research/The Norwegian Radium Hospital (Norway)
O. Solheim, Institute for Cancer Research/The Norwegian Radium Hospital (Norway)
Johan Moan, Institute for Cancer Research/The Norwegian Radium Hospital (Norway)
Karl-Erik Giercksky, Institute for Cancer Research/The Norwegian Radium Hospital (Norway)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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