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Proceedings Paper

Measurement of the photodynamic dose in an optical phantom
Author(s): Emma J. Hudson; Mark R. Stringer; Jack Schofield; John Griffiths; Michael A. Smith
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Paper Abstract

The illumination of a mixture of the photosensitizer methylene blue and the reagent tetraphenylcyclopentadienone by 630 nm light results in a change in the absorption spectrum of the mixture dependent on the light energy absorbed. The absorption peak of the reagent at 500 nm is used to quantify the photodynamic response by placement of small capillary tubes containing the mixture within an optical phantom. The light distribution within the phantom was measured simultaneously. The fluence rate predicted by diffusion theory is correlated to that of the photodynamic response. Methylene blue is commonly used as a standard photosensitizer and this study also allows comparison of the relative photodynamic effects of different photosensitizers.

Paper Details

Date Published: 1 March 1995
PDF: 5 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203443
Show Author Affiliations
Emma J. Hudson, Univ. of Leeds (United Kingdom)
Mark R. Stringer, Univ. of Leeds (United Kingdom)
Jack Schofield, Univ. of Leeds (United Kingdom)
John Griffiths, Univ. of Leeds (United Kingdom)
Michael A. Smith, Univ. of Leeds (United Kingdom)

Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting
Denis A. Cortese, Editor(s)

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