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Proceedings Paper

Fluorescence diagnostics of head and neck cancer utilizing oral administration of delta-amino levulinic acid
Author(s): Katarina Svanberg; Ingrid Wang-Nordman; R. Rydell; A. Elner; J. Wennerberg; Laudelina C. Pais Clemente; E. Cardosa; R. Pratas; Manuel P. Pais Clemente; Stefan Andersson-Engels; Sune Svanberg
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Paper Abstract

Tissue fluorescence measurements utilizing a point monitoring fluorosensor and a multi-color fluorescence imaging system were performed in patients with various malignant tumors in the head and neck region. Also precancerous lesions were investigated and characterized by means of laser-induced fluorescence. Oral administration of low-dose (delta) -amino levulinic acid was used for the induction of protoporphyrin IX, which exhibits a strong fluorescence in the red wavelength region. The blue-green fluorescence emitted from the tissue natural chromophores was also utilized for tumor demarcation. By incorporating both Protoporphyrin IX and natural fluorescence in a tumor demarcation criterion a tumor demarcation with a tumor-to-normal-surrounding-tissue of about 5 - 10:1 contrast was achieved. Hypertrophic tissue did not exhibit tumor specific signals.

Paper Details

Date Published: 1 March 1995
PDF: 13 pages
Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); doi: 10.1117/12.203438
Show Author Affiliations
Katarina Svanberg, Lund Univ. Hospital (Sweden)
Ingrid Wang-Nordman, Lund Univ. Hospital (Sweden)
R. Rydell, Lund Univ. Hospital (Sweden)
A. Elner, Lund Univ. Hospital (Sweden)
J. Wennerberg, Lund Univ. Hospital (Sweden)
Laudelina C. Pais Clemente, Porto Univ. Hospital (Portugal)
E. Cardosa, Porto Univ. Hospital (Portugal)
R. Pratas, Porto Univ. Hospital (Portugal)
Manuel P. Pais Clemente, Porto Univ. Hospital (Portugal)
Stefan Andersson-Engels, Lund Institute of Technology (Sweden)
Sune Svanberg, Lund Institute of Technology (Sweden)


Published in SPIE Proceedings Vol. 2371:
5th International Photodynamic Association Biennial Meeting

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